Blood clots form when certain blood cells and other substances stick together. If a blood clot forms inside one of your arteries, it can travel in your bloodstream to your heart or brain. Once there, the clot can cause a heart attack or stroke. Blood clots can also form in the veins deep inside your body. These types of clots are called deep vein thrombosis DVT. If these clots break loose, they can travel in your bloodstream and block blood flow to your lungs. This condition is called a pulmonary embolism PE.
Your risk of getting dangerous blood clots is increased by certain conditions and situations, such as:. In all of these situations, your blood is prevented from flowing freely around your body.
When this happens, your platelets can start clumping together inside your blood vessels. Platelets produce substances that activate clotting factors in your blood.
Clotting factors are proteins made by your liver. When activated, clotting factors lead to the formation of blood clots. Xarelto is a type of drug called a direct-acting anticoagulant DOAC. It works by attaching to the activated blood clotting factor called factor Xa.
When Xarelto attaches to factor Xa, it stops the clotting factor from working. This makes your blood less able to form clots. Xarelto is used to both treat and prevent certain types of clots. This allows your body to dissolve the clots naturally.
However, you may notice side effects from Xarelto during treatment. Xarelto may last in your body for 1 to 3 days after you stop taking it.
In healthy adults ages 20 to 45 years, the drug lasts for about 25 to 45 hours after their last dose. In people ages 60 to 75 years, the drug lasts for about 55 to 65 hours after their last dose. Your insurance plan may require you to get prior authorization before approving coverage for Xarelto. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the request and let you and your doctor know if your plan will cover Xarelto.
If you need financial support to pay for Xarelto, or if you need help understanding your insurance coverage, help is available. Janssen Pharmaceuticals, Inc. If Xarelto is taken during pregnancy, it could increase the risk of bleeding in both the mother and her fetus. In animal studies , fetal harm was seen when the drug was given to pregnant females. Anticoagulants other than Xarelto are usually preferred for treating and preventing blood clots in pregnant women. This is because more is known about the safety of using certain other anticoagulants during pregnancy.
If you do take Xarelto during pregnancy, see your doctor right away if you have any vaginal bleeding, feel dizzy or weak, or have any other symptoms of bleeding. This drug has boxed warnings. And if you have heart disease or disease in your arteries, stopping Xarelto increases your risk of heart attack and stroke. The risk is also higher if you take drugs that affect your ability to form blood clots. The risk is also higher if you have had difficult or repeated epidural or spinal punctures in the past, have a history of problems with your spine, or have had surgery on your spine.
Before taking Xarelto, talk with your doctor about your health history. Xarelto may not be right for you if you have certain medical conditions or other factors affecting your health. These include:. Using more than the recommended dosage of Xarelto can lead to serious side effects.
You can also call the American Association of Poison Control Centers at or use their online tool. But if your symptoms are severe, call or go to the nearest emergency room right away. When you get Xarelto from the pharmacy, the pharmacist will add an expiration date to the label on the bottle.
This date is typically 1 year from the date they dispensed the medication. The expiration date helps guarantee that the medication is effective during this time. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it. How long a medication remains good can depend on many factors, including how and where you store the medication.
Avoid storing this medication in areas where it could get damp or wet, such as in bathrooms. This helps prevent others, including children and pets, from taking the drug by accident. It also helps keep the drug from harming the environment. The FDA website provides several useful tips on medication disposal.
You can also ask your pharmacist for information on how to dispose of your medication. Xarelto contains the direct-acting anticoagulant DOAC rivaroxaban. It works by binding to and inhibiting blood clotting factor Xa.
This reduces the production of thrombin, and subsequently fibrin, in the clotting cascade. With lowered production of thrombin, less platelet aggregation occurs. Cmax is reached 2 to 4 hours after oral dosing. Metabolites are cleared in the urine and feces. The other half of the dose is excreted as unchanged drug, mainly in the urine and a small amount in the feces. In healthy adults ages 20 to 45 years, the terminal half-life of rivaroxaban is between 5 and 9 hours. Half-life increases to between 11 and 13 hours in people ages 60 to 76 years.
Reduced doses are recommended in people with certain renal issues. Hepatic impairment can also increase exposure to rivaroxaban. Xarelto should be avoided in people with moderate to severe hepatic impairment Child-Pugh B or C and in people with hepatic disease involving coagulopathies. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date.
However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. A thrombosis is a blood clot that has caused a blockage in a blood vessel. Here, learn about symptoms, prevention techniques, treatments, and more. Find information about cost and warfarin, how generic and brand-name prices compare, what financial assistance is available, and more.
Arterial thrombosis occurs when a blood clot forms in an artery. It can have life threatening consequences. Learn more. Get the facts on Xarelto's dosages. You can also learn how to take the drug, which form it comes in, and more. Xarelto rivaroxaban , which is used to treat and prevent certain blood clots, can cause side effects such as fatigue.
Learn how to manage these side…. Xarelto rivaroxaban. What is Xarelto? Xarelto generic. Xarelto side effects. Xarelto dosage. Xarelto uses. Xarelto use with other drugs. Xarelto vs. Alternatives to Xarelto. Xarelto and alcohol. Common questions about Xarelto. Xarelto interactions. Reversal of Xarelto. How to take Xarelto. How Xarelto works. Xarelto cost. Xarelto and pregnancy. Xarelto and birth control. Xarelto and breastfeeding.
Xarelto precautions. Xarelto overdose. Xarelto expiration, storage, and disposal. Professional information for Xarelto. The most common side effect of rivaroxaban is bleeding more easily than normal, such as having nosebleeds, heavier periods, bleeding gums and bruising. It tends to happen in the first few weeks of treatment or if you're unwell. Always carry your anticoagulant alert card with you.
Show it to your doctor or dentist before you have surgery or dental treatment. It's important they know you're taking rivaroxaban, as it may put you at risk of bleeding. Rivaroxaban is also called by the brand name Xarelto. Rivaroxaban can be taken by adults aged 18 and over. Rivaroxaban is not suitable for some people. Tell your doctor if you: have ever had an allergic reaction to rivaroxaban or any other medicine are trying to get pregnant or you're already pregnant — rivaroxaban can be harmful to your baby have liver problems are taking any other medicines that affect blood clotting, such as warfarin have any injuries that are currently bleeding a lot such as a wound or a stomach ulcer are taking the herbal remedy St John's wort often taken for depression have antiphospholipid syndrome , a condition that affects the immune system and makes you more likely to get blood clots.
It's very important to take rivaroxaban as your doctor has told you. If you have trouble swallowing pills, speak to your doctor or pharmacist. Dosage Your dose of rivaroxaban depends on why you're taking it. If you have: a heart condition called atrial fibrillation — the usual dose is 20mg a day. But your doctor might prescribe a lower dose if you have kidney disease and are at a higher risk of bleeding.
You might need to take a dose of 15mg twice a day for the first few weeks of taking rivaroxaban. If you have kidney disease and are at a higher risk of bleeding, your doctor may prescribe a lower dose. What if I forget to take it? What you need to do depends on the dose you take.
If you usually take: 10mg, 15mg or 20mg once a day — take a dose as soon as you remember, unless it's nearly time for your next one.
Take your next dose at the usual time and then carry on as normal. Never take more than 1 dose in a single day. You can take 2 x 15mg tablets at the same time to get a total of 2 doses in 1 day.
Never take more than 2 doses in 1 day. Do not take a double dose to make up for a missed one. Take your next dose at the usual time, and then carry on as normal. It's very important that you remember to take rivaroxaban every day. If you forget doses often, it may help to set an alarm to remind you. If you're worried, contact your doctor or pharmacist.
What if I take too much? How long will I take it for? Anticoagulant alert card Your doctor or pharmacist will give you an anticoagulant alert card. Switching from warfarin to rivaroxaban If you need to switch from warfarin to rivaroxaban, your doctor will advise you when to stop taking warfarin.
This is to help decide exactly when you should start taking rivaroxaban. Switching from rivaroxaban to warfarin If you need to switch from rivaroxaban to warfarin, you may need to take both medicines together for a few days. This is to help decide exactly when you should stop taking rivaroxaban. Less serious bleeding It's usual to bleed more easily than normal while you're taking rivaroxaban.
The kind of bleeding you might have includes: periods that are heavier and last longer than normal bleeding for a little longer than usual if you cut yourself occasional nosebleeds that last for less than 10 minutes bleeding from your gums when you brush your teeth bruises that come up more easily and take longer to fade than usual This type of bleeding is not dangerous and should stop by itself.
Things you can do to help yourself Cuts — press on the cut for 10 minutes with a clean cloth. Nosebleeds — find out how to stop a nosebleed or watch this video on stopping nosebleeds. Bleeding gums — if your gums are bleeding, try using a soft toothbrush and waxed dental floss to clean your teeth. Bruises — these are harmless, but can be unsightly. It might help to make them fade more quickly if you put an ice pack wrapped in a towel over the bruise for 10 minutes at a time several times a day.
What you can do to prevent bleeding While you're taking rivaroxaban, be careful when you do activities that might cause an injury or a cut or bruising.
It can help to: stop playing contact sports or other activities than can cause a head injury, such as football, rugby, hockey and horse riding wear gloves when you use sharp objects like scissors, knives and gardening tools stop wet shaving or removing hair with wax - use an electric razor or hair-removing cream instead take dentures false teeth or retainers out for a few hours a day, if you wear them, to give your gums a rest - do not wear dentures or retainers that do not fit properly tell your doctor, dentist or nurse that you take rivaroxaban before you have any medical or dental procedures or surgery - this includes vaccinations and routine appointments with the dental hygienist Serious bleeding Occasionally, you can have serious bleeding from taking rivaroxaban.
This can be dangerous and needs urgent medical attention. If you have serious bleeding, stop taking rivaroxaban. Common side effects These common side effects happen in more than 1 in people. These may be symptoms of a serious kidney problem.
Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done. Do not suddenly stop taking this medicine without first checking with your doctor.
Doing so, may increase your risk of having a stroke. Make sure your doctor knows if you are pregnant or planning to become pregnant during treatment with this medicine. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal eg, St. John's wort or vitamin supplements. Along with its needed effects, a medicine may cause some unwanted effects.
Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised. A single copy of these materials may be reprinted for noncommercial personal use only. Drugs and Supplements Rivaroxaban Oral Route. If you take rivaroxaban twice a day for the treatment of a DVT or PE, take the missed dose as soon as you remember it on that day. You may take 2 doses at the same time to make up for the missed dose.
Resume your regular dosing schedule on the next day. Do not take a double dose to make up for a missed one. Rivaroxaban prevents blood from clotting normally so it may take longer than usual for you to stop bleeding if you are cut or injured.
This medication may also cause you to bruise or bleed more easily. Call your doctor right away if bleeding or bruising is unusual. Rivaroxaban may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program.
In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to rivaroxaban. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital.
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