Patients treated with theophylline often have low plasma PLP concentrations, which could contribute to the neurological and central nervous system side effects associated with theophylline, including seizures [ 9 , 33 ].
The federal government's Dietary Guidelines for Americans notes that "Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily through foods.
In some cases, fortified foods and dietary supplements are useful when it is not possible otherwise to meet needs for one or more nutrients e. For more information about building a healthy dietary pattern, refer to the Dietary Guidelines for Americans and the U. Department of Agriculture's MyPlate. This fact sheet by the Office of Dietary Supplements ODS provides information that should not take the place of medical advice. We encourage you to talk to your healthcare providers doctor, registered dietitian, pharmacist, etc.
Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice. Updated: March 26, History of changes to this fact sheet. Find ODS on:. Strengthening Knowledge and Understanding of Dietary Supplements.
Health Information Health Information. References Institute of Medicine. Food and Nutrition Board. McCormick D. Vitamin B6. In: Bowman B, Russell R, eds. Present Knowledge in Nutrition. Modern Nutrition in Health and Disease. Department of Agriculture, Agricultural Research Service. FoodData Central , Dietary sources of nutrients among US adults, to J Am Diet Assoc ; Food and Drug Administration. Natural Medicines Comprehensive Database.
Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. J Matern Fetal Neonatal Med ; Dietary supplement use in the United States, J Nutr ; Am J Clin Nutr ; Diseases associated with defects in vitamin B6 metabolism or utilization. Annu Rev Nutr ; Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis.
Arthritis Res Ther ;7:R Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. J Intern Med ; Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial. Stroke ; Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial.
JAMA ; Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention VISP randomized controlled trial. Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. Cancer incidence and mortality after treatment with folic acid and vitamin B Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials.
Arch Intern Med ; Relations of vitamin B, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. The effect of vitamin B6 on cognition. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ ; Pyridoxine vitamin B6 therapy for premenstrual syndrome.
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Here are 13 of the best vitamin D supplements, according…. Health Conditions Discover Plan Connect. Your body cannot produce vitamin B6, so you must obtain it from foods or supplements. Here are 9 health benefits of vitamin B6, backed by science.
Share on Pinterest. Vitamin B6 plays an important role in mood regulation. Summary Low levels of vitamin B6 in older adults have been linked to depression, but research has not shown that B6 is an effective treatment for mood disorders. However, studies have not proven the effectiveness of B6 in improving brain health.
More research is needed to understand the effectiveness of vitamin B6 in treating anemia in populations other than those at increased risk for B vitamin deficiency, such as pregnant women and older adults Summary Not getting enough vitamin B6 can lead to low hemoglobin and anemia, so supplementing with this vitamin may prevent or treat these issues.
Summary Some research has indicated that high doses of vitamin B6 may be effective at decreasing anxiety and other mood issues associated with PMS due to its role in creating neurotransmitters. Summary Vitamin B6 supplements in doses of 30—75 mg a day have been used as an effective treatment for nausea and vomiting during pregnancy.
Vitamin B6 may prevent clogged arteries and minimize heart disease risk. Human research also shows a beneficial effect of B6 in preventing heart disease. Summary Vitamin B6 may help reduce high homocysteine levels that lead to narrowing of arteries. This may minimize heart disease risk. May Help Prevent Cancer. Getting enough vitamin B6 may lower your risk of developing certain types of cancer. Summary Some observational studies suggest a link between adequate dietary intake and blood levels of vitamin B6 and a decreased risk of certain types of cancer, but more research is needed.
Additionally, adequate blood levels of B6 may prevent issues that affect the retina. However, more research is needed. Summary Inflammation associated with rheumatoid arthritis may lower blood levels of vitamin B6.
Supplementing with high doses of B6 may help correct deficiencies and reduce inflammation, but more research is needed to confirm these effects.
Vitamin B6 Food Sources and Supplements. You can get vitamin B6 from food or supplements. Summary Most people can get adequate vitamin B6 through their diet. In some cases, taking higher amounts of vitamin B6 from supplements under the supervision of a doctor may be beneficial. Getting too much vitamin B6 from supplements can cause negative side effects. Summary Too much vitamin B6 from supplements can cause damage to nerves and extremities over time. Vitamin B6 may have given rise to Earth's first oxygen-producing organisms , according to researchers at the University of Illinois.
Around 2. Scientists have long held that this rise in oxygen, called the Great Oxygenation Event, was tied to the arrival of the first photosynthetic organisms. Oxygen is a byproduct of photosynthesis , which uses sunlight to turn carbon dioxide into sugary foods.
But nobody knew why these oxygen-producing organisms emerged in the first place. Researchers found that the oldest oxygen-based process involved the production of pyridoxal, a form of vitamin B6, about 2. Manganese catalase breaks down hydrogen peroxide into water and oxygen. Early organisms may have come across this enzyme when trying to cope with environmental hydrogen peroxide, which some geochemists believe was abundant in Earth's glaciers at the time and was released by the bombardment of solar radiation.
The organisms essentially got the oxygen they needed to produce pyridoxal by breaking down the glacial hydrogen peroxide with manganese catalase.
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